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Blood in stool while taking tirzepatide (Mounjaro, Zepbound) is not a recognized side effect in FDA prescribing information, but warrants immediate medical evaluation

The FLOW study, an international trial of several thousand patients with kidney disease and type 2 diabetes, started in 2019, but the guideline-based recommendation for SGLT2 inhibitors as kidney-disease therapy did not emerge until 2022

Nevertheless, Matsumoto et al

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