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Additional sources of O 2 generation come from nicotinamide adenine dinucleotide phosphate oxidase (NADPH) [15], nitric oxide synthase in peroxisomes [20], neutrophils (oxidative burst) [21], lysosome and microsomes [22,23]

doi: 10.1038/nchembio.2239 30 JiangXStockwellBRConradM

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Researchers designing combination protocols typically run controls with each compound in isolation alongside the combination arms to distinguish additive from synergistic effects and to identify which compound is driving each observed outcome

It plays a vital role in protecting our skin against free radicals that can be caused by our environment, including factors like pollution, smoking and radiation