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It has been studied for over 30 years across 100+ publications for its role in tissue repair, gut healing, and anti-inflammatory activity

Endocrine Practice, 28 (1), 45-55

It hits MC1R, MC3R, MC4R, and MC5R, creating systemic effects well beyond tanning (such as appetite suppression and sexual arousal)

Of course, there is some degree of variability in results with these types of treatments, because how well your body reacts depends upon its max output ability for collagen creation, which declines with age and is always less for certain people (genetic predisposition)

Depletion of the microbiome alters the recruitment of neuronal ensembles of oxycodone intoxication and withdrawal (in Eng)