A meta-analysis combining all three studies confirmed ontamalimabs superiority over placebo in UC patients across multiple outcomes: clinical remission (RR = 2.17, 95% CI 1.42.32, p 1, while secondary outcomes include clinical response, endoscopic remission and improvement, histologic-endoscopic mucosal improvement, and quality of life measures using the IBDQ questionnaire, evaluated over a 52-week double-blind treatment period comprising 12 weeks induction and 40 weeks maintenance with optional 40-week open-label extension
Studies in the American Journal of Clinical Nutrition show that people who combine strength training with GLP-1 medications achieve 35% greater fat-loss-to-muscle-loss ratios than those using medication without exercise
This hormone plays a key role in regulating appetite, insulin response, and digestion
[1] Simultaneously, it suppresses glucagon secretion from pancreatic alpha cells, which helps prevent the liver from releasing excess glucose into the bloodstream
Patients can experience diarrhea, nausea, constipation and vomiting
Menstrual changes concern some women