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J Clin Invest (2016) 126(5):185770

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We need to emphasize that our patient demonstrated a number of these risk factors: she was elderly and malnourished, and had diabetes and chronic kidney disease as well as sepsis, and had been unwell for three months

The mechanism: IGF-1 receptor activation in renal tubules increases sodium reabsorption, expanding plasma volume and driving fluid into interstitial spaces

Complications of surgery include hoarseness, injury to the recurrent laryngeal nerve, hypocalcemia due to damage to the parathyroid glands, and scarring (Genere and Stan 2019)