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Structure of bacterial glutathione-S-transferase maleyl pyruvate isomerase and implications for mechanism of isomerisation
Both enzymes, GPX7 and GPX8, are located in the endoplasmic reticulum and are necessary enzymes involved in the oxidative folding of endoplasmic reticulum proteins, and GPX8 also plays an important role in the regulation of Ca 2+ in the endoplasmic reticulum
Their generosity and willingness to contribute to research are essential for advancing the understanding and treatment of NPH and related neurological conditions
SLC25A39 as well as mitochondrial GSH may also represent promising drug targets for cancer, since manipulating SLC25A39 functioning or mitochondrial GSH in tumor cells may induce selective oxidative stress, leading to cell death
Clin Ophthalmol 8:21832188 Grzybowski A et al (2020) The role of systemic antimicrobials in the treatment of endophthalmitis: a review and an international perspective
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