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The results of that fairly routine clinical brain MRI/MRS scan piqued my interest because and here are the answers to your how? and why? questions above they revealed elevations of ventricular lactate similar to those that we had observed in patients with primary mitochondrial disorders, which I was investigating at the time as a Radiology faculty member at Columbia University Medical Center. Those increased lactate levels are basically synonymous with mitochondrial dysfunction We have found elevated ventricular lactate in nearly every disorder in which mitochondrial dysfunction has been implicated

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33 , 34 After oral administration, absorption of glutathione is very poor mainly due to hydrolysis by intestinal and hepatic -glutamyltransferase as mentioned above, and for that reason, most therapeutic approaches using the oral route struggle to achieve results and the patients seek less safe treatments like intravenous treatment often under uncontrolled situations which may not be medically supervised, in some countries