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, Ali, N

Moreover, several studies suggest that 4-HNE can adduct with LKB1 to inhibit the activity of AMPK and further activate the mTOR pathway, resulting the disabled autophagy initiation [147, 162, 163]

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Molecules that act by directly binding GPCRs are either orthosteric (bind in the same pocket as the natural ligand) or allosteric (bind in a different pocket)