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Aging manifests as a highly complex, temporally evolving process driven by interconnected molecular pathways, rendering monotherapies, such as senolytics, insufficient to achieve comprehensive phenotypic reversal
of subjects CL/f=Total body clearance after oral dosing Vd/f=Volume of distribution calculated after oral dosing These data indicate that glimepiride did not accumulate in serum, and the pharmacokinetics of glimepiride were not different in healthy volunteers and in Type 2 diabetic patients
