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During adolescence, high insulin levels caused by IR may disrupt the gonadotropin-releasing hormone (GnRH) signaling pathway and induce HA through multiple pathways, thereby affecting the establishment of ovulatory function

The substitution at position 2 is the functionally important one: it blocks cleavage by dipeptidyl peptidase-4, the protease that degrades native GRF within minutes

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The oral mucosa is primarily involved in fewer than 1% of melanomas, and the most common locations are the palate and maxillary gingiva

Sitagliptin phosphate: a DPP-4 inhibitor for the treatment of type 2 diabetes mellitus