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However, we cannot rule out the possibility that the structural variations we observed were caused by the non-native buffer conditions in our cryo-EM studies

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To confirm the morphological analysis of the EP screen, cells were collected at the termination of the screen (day 2) and a number of DE markers were analysed using RT-qPCR: FOXA2, SOX17, HHEX and CER1 (see Fig

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