Our findings suggest that Metformin has a greater predicted neuroprotective impact compared to 38 other DM2 DMTs, including Semaglutide, that target the DM2-AD comorbidity network, primarily by engaging key metabolic and neuroinflammatory pathways and demonstrating antiviral properties against herpesviruses
This could potentially be run as a single study with the induction trial proposed above, however we would suggest that results be published in two phases so that the very short-term induction data is not held back while waiting for success rate data
NMDA receptor antagonists prevent glutamate from driving GABAergic inhibitory neurons, resulting in a loss of inhibitory control over excitatory projections to the cerebral cortex (Newcomer et al
While early research is promising, it is still an experimental compound with limited human data
For example, M1 -polarized macrophages mediate tumor cell death while the M2 macrophages promote tumor growth (62, 63)
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