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Mix thoroughly until the solution is fully dispersed and the cream is homogeneous

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a 2026 orthopaedics review confirms receptor desensitization is a recognized effect of prolonged or high-frequency use (JAAOS Global, 2026)

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BV2 cells were seeded into 96-well plates (1104 cells/well) for 12 h, and then treated with different doses (300, 600, 900 or 1,000 nM) of semaglutide for 20 h at 37C