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Figure 2 In further characterizing this paracrine effect, the field has employed several different models of selective inhibition of proglucagon expression to more directly investigate the relative contributions of gut- versus islet-derived proglucagon products to glucose homeostasis ( Figure 2 )

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Patients with Hashimoto's typically present with symptoms of hypothyroidism including fatigue, weight gain, cold intolerance, constipation, dry skin, hair loss, and cognitive difficulties such as poor concentration or memory problems

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