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X-variables with VIP scores, such as Rac1GTP levels in PMN (Rac1(PMN)), Rac1GTP in PBMC (Rac1(PBMC)), and L, are more significant in discriminating between classes in PLS-DA as shown for the response (Y) variables represented by gram bacteria class and controls ( Figure 6B )

These findings highlight the limitations of using rat models to infer human tissue distribution due to interspecies differences in drug metabolism and pharmacokinetics (128)

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Gupta GD, Coyaud , Gonalves J, Mojarad BA, Liu Y, Wu Q, Gheiratmand L, Comartin D, Tkach JM, Cheung SW, et al

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