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Cautions for the wider drug class Class-level Approved GLP-1 medicines carry label warnings about pancreas inflammation, gallbladder problems, thyroid tumours seen in rodent studies, and low blood sugar when combined with insulin or sulfonylureas (a diabetes drug group)

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\Trackable Results: Changes in certain blood markers, including IGF-1, can be used to monitor the effectiveness of CJC-1295

P = .001) No significant effect on mental QoL or PANSS-6 scores Adverse Effects GI symptoms more frequent in semaglutide group Slightly higher hospitalization rates in semaglutide group No difference in the number of serious adverse events between groups Clinical Implications This study confirms that semaglutide is safe and highly effective for improving metabolic health in patients with schizophrenia receiving antipsychotics