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On the other hand, majority of IGF-I actions are mediated through the union of IGF-I to its putative receptor, IGF-IR, a tyrosine kinase that is one of the most potent natural activators of Akt pathway, involving among others: mTOR, MAPK, GSK3, FOXO, HDM2, Grb2 and Shc systems, all of them closely related with cell survival, growth and proliferation[1517]