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You can gradually increase to the full dose as your body adjusts

The increased level of insulin increases IGF-1 production by stimulating GH signaling ( 2 ( IGF-1 has been associated with the development and progression of some cancer types due to its function in activating the MAPK and PI3K signaling pathways ( in vivo study, the presence of high IGF-1 levels in the primary tumor environment tended to induce cancer cells to metastasize to bone, and cancer cell lines that highly expressed IGF1R were prone to display enlarged bone mass (50, 51)

Think: salmon with roasted Brussels sprouts, or avocado with scrambled eggs and sauted spinach

FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice

Drug therapy, such as anti-VEGF therapy, has led to drug resistance in clinical practice

Youre noticing rapid weight swings between sessions (which often is water weight but still may be worthwhile to bring up)