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Studies show that the transcription factor FOXO4 plays a protective role in senescent cells by maintaining the protein p53 in a sequestrated state within nuclear structures, thereby inhibiting its ability to initiate apoptosis

A study conducted on PD model mice shows that the administration of exedin-4 both prevented microglial activation in the substantia nigra pars compacta and significantly reduced the neuronal loss in that region, as well as with striatal dopaminergic nerve fibers [70]

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Another 5 l IP1 stimulation buffer containing ligand was added to the cells, and the incubation lasted for 30 min at R.T

& Lao, J

The disease is caused by the amplification of the CAG trinucleotide repeat in the first exon of the Huntingtin gene on chromosome 4 (Stoker et al., 2022)