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American Journal of Clinical Nutrition 1994;60(1):211

If you were prescribed B12 injections for a documented deficiency, your doctor will reassess whether the injection schedule needs adjusting

Vitamin B12 Deficiency & Chronic Disease Vitamin B12 deficiencies are associated with chronic diseases

Freezing and thawing can fracture the peptide structures

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Injectable B12 has few direct drug interactions, but certain medications can interfere with B12 absorption or measurement: Chloramphenicol: This antibiotic may antagonise the haematological response to B12 in some patients, potentially preventing the expected rise in red blood cell count