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How many post-GLP-1 patients have you treated
Based on the price disclosed by the worker, the monthly cost of Mazdutide falls between that of Eli Lilly's Tirzepatide (Mounjaro) and Novo Nordisk's Semaglutide (Ozempic and Wegovy)
However, in a sensitivity analysis of the REWIND study with dulaglutide, the relative risk reduction for a 40% or 50% decrease in eGFR was 30% and 44%, both significant, in the dulaglutide group compared to placebo, respectively.92 This lower risk of developing macroalbuminuria was also confirmed in an exploratory analysis of the ELIXA (lixisenatide) study.93 In the EXSCEL study (exenatide LAR), renal episodes were analyzed as additional microvascular episodes, and no differences were observed in the risk of episodes related to decreased eGFR, but differences were observed in the composite episode, which included decreased eGFR and macroalbuminuria, although only after adjustment94 (Table 2)
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A major factor contributing to the high cost of weight-loss drugs is that there are only two major pharmaceutical companies producing the drugs right now, so options are limited
A phase 3 trial published in 2024 showed tirzepatide cut AHI scores substantially and improved weight, blood pressure, and systemic inflammation
