Marso et al
Low E, Alimohammadiha G, Smith LA, Costello LF, Przyborski SA, von Zglinicki T, et al
Safety, Tolerability & Regulatory Status Safety Profile GHK-Cu demonstrates an excellent safety profile for cosmetic use: Naturally occurring in humans (plasma, saliva, urine) Non-sensitizing in standard patch testing at cosmetic concentrations Long history of topical application in anti-aging and wound care products Minimal reported adverse reactions at appropriate doses Usage Levels and Tolerability Regulatory Status EU : Permitted as a cosmetic ingredient with standard safety assessments US/Asia-Pacific : Allowed under respective cosmetic regulations Formulators must : Perform product-specific safety evaluations, including SDS review, toxicological profiles, and margin of safety calculations Addressing Copper Uglies Literature occasionally references theoretical over-stimulation of MMPs leading to collagen breakdown (sometimes called copper uglies)
That medical relationship matters, especially with a medication that affects appetite, digestion, blood sugar response, and dosing over time
117,134 Overall, NAC at a dose of 6002400 mg per day appears to be safe for children over the age of 2 years
Townsend RR, Kapoor S, & McFadden, CB
