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These modifications confer an extended elimination half-life of approximately 116.7 h, facilitating once-weekly dosing

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A recent finding shows that soluble protein cargo lipoprotein lipase can also be sorted into sphingomyelin-rich secretory vesicles through binding to an integral membrane protein Syndecan-1, which depends on its TMD length to target sphingomyelin-rich domains (Sundberg et al., 2019)

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Oncotarget 6(15):1301913035 Kane RC, Bross PF, Farrell AT, Pazdur R (2003) Velcade: U.S

10.1080/17512433.2020.1736041 32 StorgaardH.ColdF.GluudL