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Anti-inflammatory NF-B Modulation MC1R and MC3R activation by melanocortin peptides has been shown to suppress NF-B nuclear translocation and downregulate pro-inflammatory cytokine production (TNF-, IL-6, IL-1) in macrophage and keratinocyte models, suggesting a role in cutaneous inflammatory signaling research (Luger et al., Journal of Investigative Dermatology, 1997)

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This can occur even with perfect technique because the capillary network is invisible from the surface

Since the rash is associated with, and worsened by dryness of the skin, most people experience a clear-cut seasonal variation generally worse in the winter