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Depression-related effects appear to be rare based on current clinical trial and post-marketing data

Sleep & Circadian Rhythm Mitochondrial respiration, antioxidant enzyme expression, and NADPH-generating pathways exhibit strong circadian regulation (21)

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Behavioral interventionsstructured nutrition coaching, strength training, and sleep hygiene optimizationproduce modest but durable weight loss (38% body weight) in motivated individuals, especially when combined with cognitive behavioral therapy for emotional eating