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A weight loss 5% occurred in 54.3, 40.4, and 21.4% of patients, respectively, and a weight loss 10% occurred in 25.2, 15.9, and 6.7% of patients, respectively

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doi: 10.1016/j.kint.2022.07.034 13 ProudfootDSkepperJNHegyiLBennettMRShanahanCMWeissbergPL

This physical limitation makes it more difficult to effectively target cells and requires higher viral doses, which can raise safety issues and complicate manufacturing