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Titration governs tolerability fast 2-week ramp to 15 mg gave 24.5% AE-discontinuation (Frias 2018)

In cognitive peptides: substitute when possible in vivo tests by cerebral organoids or primary neuronal cultures ( Replacement ), optimise experimental plan to minimise the number of animals ( Reduction ), use appropriate anaesthesia and analgesia during invasive procedures ( Refinement )

Capella-Gutirrez S, Silla-Martnez JM, Gabaldn T

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Smith, J., Adams, I