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Male fertility issues can be caused or contributed to by all of the following: Health and Lifestyle Causes Medical Causes Cancer Medication side effects Hormonal disorders Androgen insensitivity Androgen excess State Estrogen excess state Testicular Failure Congenital or developmental testicular disorder (e.g., Klinefelter syndrome) Testicular Trauma Varicocele Obstruction of the reproductive tract Environmental Causes/Other Common Male Infertility Diagnoses Azoospermia Azoospermia is the medical term used to describe when there is no sperm present in a mans ejaculate