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Phase 2 trial (NEJM, 2023) The landmark Phase 2 trial, published in the New England Journal of Medicine, randomized 338 adults with obesity to receive weekly subcutaneous retatrutide at doses of 1 mg, 4 mg, 8 mg, or 12 mg, or placebo, for 48 weeks

The three primary retatrutide injection sites Clinical trials for retatrutide specified three approved injection sites: the abdomen, the anterior thigh, and the posterior upper arm

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While muscle loss is standard with any diet or weight-loss regimen, loss of muscle on GLP-1s can be more dramatic, Ahmed says, causing what's been dubbed "Ozempic face," a bonier, looser-skinned look, where the muscle loss is particularly noticeable