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Hydrophobic peptides or peptides rich in basic amino acids such as arginine, lysine or histidine may require an acidic first step solvent to support full dissolution

E.OfverstedtL.-G.et al (2006)

14,15 It has also been noted that endogenous GHK declines with age, with higher levels in young healthy people as compared to older adults around age 60

This uncertainty is one of the challenges with using compounds that lack regulatory approval

Zhonghua Yi Xue Za Zhi (Taipei) 2001;64(5):259270

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