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The Great Unblocking The GLP-1 Patent Cliff, and Indias $150B Bid for Global Obesity Hegemony Anatomy of a Revolution The term paradigm shift originates with Thomas Samuel Kuhn in his 1962 landmark book The Structure of Scientific Revolutions

In trial reports, Motus (oral) delivered about 10.4 percent average weight loss in human clinical trials over six months, with a high proportion of the loss from fat instead of lean mass

Hepatology 68:361371

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IR promotes the release of reactive oxygen species (ROS), which weaken the integrity of the BBB under oxidative stress, thereby activating astrocytes and microglia, thereby increasing inflammation

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