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The enzyme glutathione reductase (GR) , utilizing the coenzyme NADPH, steps in to break the disulfide bond, recycling GSSG back into the active, reduced GSH state

[5] Topical GHK-Cu is generally considered well tolerated, yet therapy should be avoided in individuals with a known hypersensitivity to copper peptides or any vehicle component

The strongest human evidence is for the skin, where steady topical use shows about a 20 to 30 percent gain in firmness over 12 weeks

References: Regulation of glutathione synthesis

Responsible use of these products is all that is needed to ensure long-term safety