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Rev Endocr Metab Disord (2020)

Resveratrol-drug interaction using high dosage due to inactivation of CYP450 isoenzymes is also of concern [147]

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GIP is secreted by the enteroendocrine K-cells concentrated in the proximal intestines, including the duodenum and jejunum ( via both neural and endocrine mediated factors ( Incretins act on G-protein coupled receptors on the beta cells of the pancreas, leading to a cAMP mediated pathway that ultimately results in insulin secretion ( Figure 1 )