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Key research themes involving glutathione include: Scavenging of free radicals (e.g., peroxides, nitrogen dioxide, hypochlorous acid) Support of other antioxidant systems (e.g., vitamin C and vitamin E recycling) Detoxification via glutathione S-transferases and related enzymes Regulation of protein folding, disulfide-bond formation, and thiol redox status Modulation of inflammatory mediators, nitric oxide pathways, and cellular metabolism Because endogenous glutathione synthesis capacity appears to decrease with age in many models, glutathione is frequently used as both an experimental variable and a biomarker in studies of aging, disease susceptibility, and redox imbalance

83,99 The expression of antioxidant enzymes (SOD, CAT, and GPx) is largely controlled by the interaction of Nrf2 with the antioxidant response element

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The researchers noted something particularly interesting: The improvements came from supporting the bodys natural glutathione production rather than trying to supplement glutathione directly