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(laughs) David Kellner, MD: I would say the most common side effects with these medications are gastrointestinal, so nausea, diarrhea, constipation, acid reflux, and this is especially during dose increases

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Mechanistic diversity involved in the desensitization of G protein-coupled receptors

doi: 10.1016/0142-9612(95)93115-T

PMID: 28346442