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[15] [14] While mild gastrointestinal symptoms are common and often transient with GLP-1 therapy, certain warning signs warrant prompt medical evaluation
Br J Haematol 119(1):131-4, 2002
Structural and molecular differences include: Amino acid composition : Semaglutide contains specific substitutions that confer DPP-4 resistance, whereas native GLP-1 is rapidly cleaved by this ubiquitous enzyme Albumin binding : The fatty acid side chain attached to lysine at position 26 in semaglutide enables prolonged circulation through albumin binding, a property absent in natural GLP-1 Molecular stability : Structural modifications protect semaglutide from enzymatic degradation and renal clearance that rapidly eliminate native GLP-1 From a clinical perspective, natural GLP-1 cannot be administered as a therapeutic agent due to its extremely short half-life, which would require continuous intravenous infusion for sustained effect
While semaglutide has been shown to be generally safe and effective, its important to be aware of potential side effects and monitor your health closely
