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Front Immunol 9:316 Acknowledgements We thanked the Institute of Urology of Tongji Hospital for its support

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In order to experimentally validate ternary complex formation, we carried out pulldown assays based on USP14 immobilized on beads, in parallel assessments of IMPDH2 and CERT1 interactions with USP14, in the presence of representative 354 and 386 chimeras