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Tirzepatide, approved for adults aged 18+, currently has limited long-term pediatric safety data, though trials are ongoing in younger populations

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However, allocation concealment had a substantial amount of unclear ranking (29/62), and high risks of bias were found for blinding of participants/personnel (20/62) as well as blinding of outcomes (23/62)

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In addition to low L-carnitine (due to a heterozygote transporter mutation), elevated 3-methylhistidine was present, suggesting elevated muscle breakdown