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A: According to published clinical trial data for FDA-approved medications: Wegovy (semaglutide 2.4 mg): Average 15% body weight loss at 68 weeks (approximately 33 pounds for 220-pound individual) Zepbound (tirzepatide 15 mg): Average 20% body weight loss at 72 weeks (approximately 44 pounds for 220-pound individual) Critical Context : These represent average results from controlled clinical trials where participants also followed reduced-calorie diets and increased physical activity

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The GCN5-CITED2-PKA signalling module controls hepatic glucose metabolism through a cAMP-induced substrate switch