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doi: 10.1111/j.1939-1676.1993.tb01030.x

Similarly, the neuroprotective effect of sinomenine on cognitive dysfunction following type 2 diabetes mellitus is achieved through the inhibition of ferroptosis in hippocampal neurons via the classical ferroptosis signaling pathway (epidermal growth factor/nuclear factor erythroid derived 2-related factor 2 (Nrf2)/heme oxygenase 1) and the microbiota-gut-brain axis [101]

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4 More recently, the FDA Reauthorization Act of 2017 (FDARA) made a reference encouraging the enrollment of more diverse patient populations, and the Final Rule for Clinical Trials Registration and Results Information Submission (42 CFR Part 11) went into effect in January 2017

(1963) and Clarke et al