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GSH-activated prodrugs, including disulfide- and diselenide-linked conjugates, are selectively activated in tumors, enabling high drug loading and targeted delivery

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Because of this pleiotropic effect, distinguishing between direct, i.e., via agonist-receptor interaction, and indirect effects of these agonists in vivo is challenging

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References 1.Tsur AM, Twig G

Comorbid conditions such as hypertension and dyslipidemia also contribute to an increased risk of developing neuropathy