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Despite such a great overall efficacy of PDE5i treatment for ED, some limitations exist, mainly attributable to contraindications and to potential adverse effects and related discontinuation of treatment

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Additionally, a co-culture system of MCECs and MPMs revealed that GHK-Cu facilitated MCECs healing, impaired by DSS, by upregulating ZO-1 and Occludin expression

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Notably, lactate production and export to neurons is a key astrocytic function, as lactate supports axonal survival even in oxygen-rich conditions

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