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The team was hoping to hook a protein (or proteins) that, post-GLP-1 activation, had a particular chemical modification called phosphorylation

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Key features Sensitive and easy-to-use colorimetric SEAP bioassay Convenient readout using QUANTI-Blue Solution Strong response to GLP-1R agonists Suitable for kinetic studies (no cell lysis required) Stability guaranteed for 20 passages Applications Therapeutic development Drug screening Release assay Glucagon-like peptide-1 (GLP-1) is an incretin hormone produced primarily by intestinal L-cells in response to rising glucose concentrations

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Back Majzoub, JA, Kronenberg, HM, Potts, JT, et al (10 Aug 1979) 'Identification and cell-free translation of mRNA coding for a pre- cursor of parathyroid secretory protein', The Journal of Biological Chemistry , 254/15, 7449-55

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