Brain Health and Longevity Glutathione protects neurons and has been linked to brain longevity
Drug class Thiazide diuretic Mechanism of action Inhibits Na/Cl symporter in the distal convoluted tubule of the kidney Excretion of sodium and water blood volume blood pressure excretion of potassium, magnesium excretion of calcium (can help prevent kidney stones) Clinical uses Hypertension (first-line therapy) Edema (heart failure, nephrotic syndrome, cirrhosis) Prevention of calcium kidney stones Pharmacokinetics Well absorbed orally Renally excreted unchanged Not a prodrug Adverse effects Hypokalemia Hyponatremia Hyperuricemia gout Hyperglycemia (mild) Hypotension Hypercalcemia Contraindications / Caution Severe renal impairment Hypersensitivity to sulfonamides Hydrochlorothiazide = Active drug Chlorthalidone = Active drug Metolazone = Active drug Thiazide diuretics work directly
If you arent thrilled about the possibility of dealing with fishy burps, NAD+ supplements improve mitochondrial functioning that wanes with age
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Dahan A, et al
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