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Clinical use showed visible improvement in skin brightness and reduction in surface pigmentation

However typical stability-indicating methods are still popular these days, use of high-resolution multi-stage mass spectrometry is becoming an apparent trend

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For the IL-17A/IL-22 fusion, significant protein engineering was required to obtain a dual activity profile in in vitro assays and to limit the peptide degradation during production, a phenomenon frequently observed for peptide fusion molecules expressed in transfected cells 30