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Remission in major depressive disorder: a comparison of pharmacotherapy, psychotherapy, and control conditions

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This paradox makes biological sense when you consider the collateral vessel activation mechanism

472 Elevated extracellular mtDNA in synovial fluid and plasma correlates with autoantibody presence and inflammation, while mtDNA mutations in synovial tissues are associated with increased TNF- and IFN signaling, establishing a self-reinforcing inflammatory cycle