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The gradient mode used to pump mobile phases A and B into the column is as follows: 016 min 95 5% A, 1619 min 5% A, 1920 min 595% A, and 2022 min 595% A

Both require once-weekly injections

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The key word in the safety data is "no increase in serious cardiovascular events." That said, the absence of evidence is not evidence of absence