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The compound significantly enhances the effectiveness of gemcitabine in intrahepatic cholangiocarcinoma by inhibiting HDAC activity and restoring expression of pro-apoptotic genes (81)

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Available as subcutaneous injection and as an oral liposomal preparation (BPC-157 LPT) for gut-focused indications

Lactate is undoubtedly involved in energy metabolism

doi:10.1021/acs.bioconjchem.4c00545

Their integration offers synergistic advantages: proteomics uncovers dynamic changes in enzyme abundance, post-translational modifications and signaling pathways, wheras metabolomics captures real-time metabolic flux, substrate-product relationships, and metabolic bottlenecks ( This study aimed to elucidate the mechanisms underlying oxidative hippocampal injury in mid-late SAE using an integrated multi-omics strategy