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After oxidative stress has passed, Grx enzymes in both the cytosol and mitochondria of cells catalyze the removal of these modifications ( The final part of this group is the thioredoxin (Trx) system, another thiol-based redox mechanism that is independent of GSH

In cancer (Table 1), CDO1 is usually silenced by promoter methylation and this is associated with poor prognosis, 70,74 implying that the shutting down of CDO1 expression favours cancer progression

PMID 18175071

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