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This sequential strategy, supported by clinical practice, avoids the risks of simultaneous dual therapy

Importantly, multiple large randomized clinical trials have since demonstrated the remarkable effect of this class of drugs in preventing adverse renal outcomes in patients with diabetic nephropathy but also a diverse range of other chronic kidney diseases 5,6

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Oral peptide delivery: Translational challenges due to physiological effects

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In this trial, both drugs helped improve these health markers, but tirzepatides added benefits could make it the top choice for many people with obesity